Boston University Systems Biology Seminars

ABSTRACTS

Frederick P. 'Fritz' Roth

Systematic analysis of genetic interactions in yeast and humans.
Sometimes two mutations together cause a phenotype that is surprising given the effects of the individual mutations.  This phenomenon defines genetic interaction.  I will describe diverse analyses of systematic studies of genetic interaction amongst engineered mutant alleles in the yeast S. cerevisiae.  I will also describe preliminary analysis of genetic interactions among natural polymorphisms in an outbred human population.
 

Xiaole Shirley Liu

ChIPing the Human Cistrome
Cistrome defines the set of cis-acting targets of a trans-acting factor on a genome scale. I will discuss our analysis of ChIP-chip on genome tiling microarrays and ChIP-seq on Solexa sequencing to discovery human cistromes. I will also discuss how to use the cistromes to understand transcriptional and epigenetic regulation of gene expression in cancer.